Heritability of Fractional Anisotropy in Human White Matter: A Comparison of Human Connectome Project and ENIGMA-DTI Data
Identifieur interne : 002D09 ( Main/Exploration ); précédent : 002D08; suivant : 002D10Heritability of Fractional Anisotropy in Human White Matter: A Comparison of Human Connectome Project and ENIGMA-DTI Data
Auteurs : Peter Kochunov ; Neda Jahanshad ; Daniel Marcus ; Anderson Winkler ; Emma Sprooten ; Thomas E. Nichols ; Susan N. Wright ; L Elliot Hong ; Binish Patel ; Timothy Behrens ; Saad Jbabdi ; Jesper Andersson ; Christophe Lenglet ; Essa Yacoub ; Steen Moeller ; Eddie Auerbach ; Kamil Ugurbil ; Stamatios N. Sotiropoulos ; Rachel M. Brouwer ; Bennett Landman ; Hervé Lemaitre ; Anouk Den Braber ; Marcel P. Zwiers ; Stuart Ritchie ; Kimm Vanhulzen ; Laura Almasy ; Joanne Curran ; Greig I. Dezubicaray ; Ravi Duggirala ; Peter Fox ; Nicholas G. Martin ; Katie L. Mcmahon ; Braxton Mitchell ; Rene L. Olvera ; Charles Peterson ; John Starr ; Jessika Sussmann ; Joanna Wardlaw ; Margie Wright ; Dorret I. Boomsma ; Rene Kahn ; Eco Jc De Geus ; Douglas E. Williamson ; Ahmad Hariri ; Dennis Van T Ent ; Mark E. Bastin ; Andrew Mcintosh ; Ian J. Deary ; Hilleke E. Hulshoff Pol ; John Blangero ; Paul M. Thompson ; David C. Glahn ; David C. Van EssenSource :
- NeuroImage [ 1053-8119 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- anatomie et histologie : Réseau nerveux, Substance blanche.
- Adulte, Anisotropie, Connectome, Enregistrements, Femelle, Humains, Imagerie par tenseur de diffusion, Jeune adulte, Mâle, Phénomènes génétiques, Études de cohortes.
English descriptors
- KwdEn :
- MESH :
- anatomy & histology : Nerve Net, White Matter.
- methods : Connectome, Diffusion Tensor Imaging.
- Adult, Anisotropy, Cohort Studies, Female, Genetic Phenomena, Humans, Male, Registries, Young Adult.
Abstract
The degree to which genetic factors influence brain connectivity is beginning to be understood. Large-scale efforts are underway to map the profile of genetic effects in various brain regions. The NIH-funded Human Connectome Project (HCP) is providing data valuable for analyzing the degree of genetic influence underlying brain connectivity revealed by state-of-the-art neuroimaging methods. We calculated the heritability of the fractional anisotropy (FA) measure derived from diffusion tensor imaging (DTI) reconstruction in 481 HCP subjects (194/287 M/F) consisting of 57/60 pairs of mono- and dizygotic twins, and 246 siblings. FA measurements were derived using (Enhancing NeuroImaging Genetics through Meta-Analysis) ENIGMA DTI protocols and heritability estimates were calculated using the SOLAR-Eclipse imaging genetic analysis package. We compared heritability estimates derived from HCP data to those publicly available through the ENIGMA-DTI consortium, which were pooled together from five-family based studies across the US, Europe, and Australia. FA measurements from the HCP cohort for eleven major white matter tracts were highly heritable (h2=0.53–0.90, p<10−5), and were significantly correlated with the joint-analytical estimates from the ENIGMA cohort on the tract and voxel-wise levels. The similarity in regional heritability suggests that the additive genetic contribution to white matter microstructure is consistent across populations and imaging acquisition parameters. It also suggests the overarching genetic influence provides an opportunity to define a common genetic search space for future gene-discovery studies. Uniquely, the measurements of additive genetic contribution performed in this study can be repeated using online genetic analysis tools provided by the HCP ConnectomeDB web application.
Url:
DOI: 10.1016/j.neuroimage.2015.02.050
PubMed: 25747917
PubMed Central: 4387079
Affiliations:
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Wright</name></author><author><name sortKey="Hong, L Elliot" sort="Hong, L Elliot" uniqKey="Hong L" first="L Elliot" last="Hong">L Elliot Hong</name></author><author><name sortKey="Patel, Binish" sort="Patel, Binish" uniqKey="Patel B" first="Binish" last="Patel">Binish Patel</name></author><author><name sortKey="Behrens, Timothy" sort="Behrens, Timothy" uniqKey="Behrens T" first="Timothy" last="Behrens">Timothy Behrens</name></author><author><name sortKey="Jbabdi, Saad" sort="Jbabdi, Saad" uniqKey="Jbabdi S" first="Saad" last="Jbabdi">Saad Jbabdi</name></author><author><name sortKey="Andersson, Jesper" sort="Andersson, Jesper" uniqKey="Andersson J" first="Jesper" last="Andersson">Jesper Andersson</name></author><author><name sortKey="Lenglet, Christophe" sort="Lenglet, Christophe" uniqKey="Lenglet C" first="Christophe" last="Lenglet">Christophe Lenglet</name></author><author><name sortKey="Yacoub, Essa" sort="Yacoub, Essa" uniqKey="Yacoub E" first="Essa" last="Yacoub">Essa Yacoub</name></author><author><name sortKey="Moeller, Steen" sort="Moeller, Steen" uniqKey="Moeller S" first="Steen" last="Moeller">Steen Moeller</name></author><author><name sortKey="Auerbach, Eddie" sort="Auerbach, Eddie" uniqKey="Auerbach E" first="Eddie" last="Auerbach">Eddie Auerbach</name></author><author><name sortKey="Ugurbil, Kamil" sort="Ugurbil, Kamil" uniqKey="Ugurbil K" first="Kamil" last="Ugurbil">Kamil Ugurbil</name></author><author><name sortKey="Sotiropoulos, Stamatios N" sort="Sotiropoulos, Stamatios N" uniqKey="Sotiropoulos S" first="Stamatios N" last="Sotiropoulos">Stamatios N. 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Nichols</name></author><author><name sortKey="Wright, Susan N" sort="Wright, Susan N" uniqKey="Wright S" first="Susan N" last="Wright">Susan N. Wright</name></author><author><name sortKey="Hong, L Elliot" sort="Hong, L Elliot" uniqKey="Hong L" first="L Elliot" last="Hong">L Elliot Hong</name></author><author><name sortKey="Patel, Binish" sort="Patel, Binish" uniqKey="Patel B" first="Binish" last="Patel">Binish Patel</name></author><author><name sortKey="Behrens, Timothy" sort="Behrens, Timothy" uniqKey="Behrens T" first="Timothy" last="Behrens">Timothy Behrens</name></author><author><name sortKey="Jbabdi, Saad" sort="Jbabdi, Saad" uniqKey="Jbabdi S" first="Saad" last="Jbabdi">Saad Jbabdi</name></author><author><name sortKey="Andersson, Jesper" sort="Andersson, Jesper" uniqKey="Andersson J" first="Jesper" last="Andersson">Jesper Andersson</name></author><author><name sortKey="Lenglet, Christophe" sort="Lenglet, Christophe" uniqKey="Lenglet C" first="Christophe" last="Lenglet">Christophe Lenglet</name></author><author><name sortKey="Yacoub, Essa" sort="Yacoub, Essa" uniqKey="Yacoub E" first="Essa" last="Yacoub">Essa Yacoub</name></author><author><name sortKey="Moeller, Steen" sort="Moeller, Steen" uniqKey="Moeller S" first="Steen" last="Moeller">Steen Moeller</name></author><author><name sortKey="Auerbach, Eddie" sort="Auerbach, Eddie" uniqKey="Auerbach E" first="Eddie" last="Auerbach">Eddie Auerbach</name></author><author><name sortKey="Ugurbil, Kamil" sort="Ugurbil, Kamil" uniqKey="Ugurbil K" first="Kamil" last="Ugurbil">Kamil Ugurbil</name></author><author><name sortKey="Sotiropoulos, Stamatios N" sort="Sotiropoulos, Stamatios N" uniqKey="Sotiropoulos S" first="Stamatios N" last="Sotiropoulos">Stamatios N. Sotiropoulos</name></author><author><name sortKey="Brouwer, Rachel M" sort="Brouwer, Rachel M" uniqKey="Brouwer R" first="Rachel M." last="Brouwer">Rachel M. Brouwer</name></author><author><name sortKey="Landman, Bennett" sort="Landman, Bennett" uniqKey="Landman B" first="Bennett" last="Landman">Bennett Landman</name></author><author><name sortKey="Lemaitre, Herve" sort="Lemaitre, Herve" uniqKey="Lemaitre H" first="Hervé" last="Lemaitre">Hervé Lemaitre</name></author><author><name sortKey="Den Braber, Anouk" sort="Den Braber, Anouk" uniqKey="Den Braber A" first="Anouk" last="Den Braber">Anouk Den Braber</name></author><author><name sortKey="Zwiers, Marcel P" sort="Zwiers, Marcel P" uniqKey="Zwiers M" first="Marcel P." last="Zwiers">Marcel P. Zwiers</name></author><author><name sortKey="Ritchie, Stuart" sort="Ritchie, Stuart" uniqKey="Ritchie S" first="Stuart" last="Ritchie">Stuart Ritchie</name></author><author><name sortKey="Vanhulzen, Kimm" sort="Vanhulzen, Kimm" uniqKey="Vanhulzen K" first="Kimm" last="Vanhulzen">Kimm Vanhulzen</name></author><author><name sortKey="Almasy, Laura" sort="Almasy, Laura" uniqKey="Almasy L" first="Laura" last="Almasy">Laura Almasy</name></author><author><name sortKey="Curran, Joanne" sort="Curran, Joanne" uniqKey="Curran J" first="Joanne" last="Curran">Joanne Curran</name></author><author><name sortKey="Dezubicaray, Greig I" sort="Dezubicaray, Greig I" uniqKey="Dezubicaray G" first="Greig I" last="Dezubicaray">Greig I. Dezubicaray</name></author><author><name sortKey="Duggirala, Ravi" sort="Duggirala, Ravi" uniqKey="Duggirala R" first="Ravi" last="Duggirala">Ravi Duggirala</name></author><author><name sortKey="Fox, Peter" sort="Fox, Peter" uniqKey="Fox P" first="Peter" last="Fox">Peter Fox</name></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name></author><author><name sortKey="Mcmahon, Katie L" sort="Mcmahon, Katie L" uniqKey="Mcmahon K" first="Katie L." last="Mcmahon">Katie L. Mcmahon</name></author><author><name sortKey="Mitchell, Braxton" sort="Mitchell, Braxton" uniqKey="Mitchell B" first="Braxton" last="Mitchell">Braxton Mitchell</name></author><author><name sortKey="Olvera, Rene L" sort="Olvera, Rene L" uniqKey="Olvera R" first="Rene L" last="Olvera">Rene L. Olvera</name></author><author><name sortKey="Peterson, Charles" sort="Peterson, Charles" uniqKey="Peterson C" first="Charles" last="Peterson">Charles Peterson</name></author><author><name sortKey="Starr, John" sort="Starr, John" uniqKey="Starr J" first="John" last="Starr">John Starr</name></author><author><name sortKey="Sussmann, Jessika" sort="Sussmann, Jessika" uniqKey="Sussmann J" first="Jessika" last="Sussmann">Jessika Sussmann</name></author><author><name sortKey="Wardlaw, Joanna" sort="Wardlaw, Joanna" uniqKey="Wardlaw J" first="Joanna" last="Wardlaw">Joanna Wardlaw</name></author><author><name sortKey="Wright, Margie" sort="Wright, Margie" uniqKey="Wright M" first="Margie" last="Wright">Margie Wright</name></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name></author><author><name sortKey="Kahn, Rene" sort="Kahn, Rene" uniqKey="Kahn R" first="Rene" last="Kahn">Rene Kahn</name></author><author><name sortKey="De Geus, Eco Jc" sort="De Geus, Eco Jc" uniqKey="De Geus E" first="Eco Jc" last="De Geus">Eco Jc De Geus</name></author><author><name sortKey="Williamson, Douglas E" sort="Williamson, Douglas E" uniqKey="Williamson D" first="Douglas E" last="Williamson">Douglas E. Williamson</name></author><author><name sortKey="Hariri, Ahmad" sort="Hariri, Ahmad" uniqKey="Hariri A" first="Ahmad" last="Hariri">Ahmad Hariri</name></author><author><name sortKey="Van T Ent, Dennis" sort="Van T Ent, Dennis" uniqKey="Van T Ent D" first="Dennis" last="Van T Ent">Dennis Van T Ent</name></author><author><name sortKey="Bastin, Mark E" sort="Bastin, Mark E" uniqKey="Bastin M" first="Mark E." last="Bastin">Mark E. Bastin</name></author><author><name sortKey="Mcintosh, Andrew" sort="Mcintosh, Andrew" uniqKey="Mcintosh A" first="Andrew" last="Mcintosh">Andrew Mcintosh</name></author><author><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name></author><author><name sortKey="Hulshoff Pol, Hilleke E" sort="Hulshoff Pol, Hilleke E" uniqKey="Hulshoff Pol H" first="Hilleke E." last="Hulshoff Pol">Hilleke E. Hulshoff Pol</name></author><author><name sortKey="Blangero, John" sort="Blangero, John" uniqKey="Blangero J" first="John" last="Blangero">John Blangero</name></author><author><name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M." last="Thompson">Paul M. Thompson</name></author><author><name sortKey="Glahn, David C" sort="Glahn, David C" uniqKey="Glahn D" first="David C." last="Glahn">David C. Glahn</name></author><author><name sortKey="Van Essen, David C" sort="Van Essen, David C" uniqKey="Van Essen D" first="David C." last="Van Essen">David C. Van Essen</name></author></analytic><series><title level="j">NeuroImage</title><idno type="ISSN">1053-8119</idno><idno type="eISSN">1095-9572</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Anisotropy</term><term>Cohort Studies</term><term>Connectome (methods)</term><term>Diffusion Tensor Imaging (methods)</term><term>Female</term><term>Genetic Phenomena</term><term>Humans</term><term>Male</term><term>Nerve Net (anatomy & histology)</term><term>Registries</term><term>White Matter (anatomy & histology)</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Anisotropie</term><term>Connectome ()</term><term>Enregistrements</term><term>Femelle</term><term>Humains</term><term>Imagerie par tenseur de diffusion ()</term><term>Jeune adulte</term><term>Mâle</term><term>Phénomènes génétiques</term><term>Réseau nerveux (anatomie et histologie)</term><term>Substance blanche (anatomie et histologie)</term><term>Études de cohortes</term></keywords><keywords scheme="MESH" qualifier="anatomie et histologie" xml:lang="fr"><term>Réseau nerveux</term><term>Substance blanche</term></keywords><keywords scheme="MESH" qualifier="anatomy & histology" xml:lang="en"><term>Nerve Net</term><term>White Matter</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Connectome</term><term>Diffusion Tensor Imaging</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Anisotropy</term><term>Cohort Studies</term><term>Female</term><term>Genetic Phenomena</term><term>Humans</term><term>Male</term><term>Registries</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Anisotropie</term><term>Connectome</term><term>Enregistrements</term><term>Femelle</term><term>Humains</term><term>Imagerie par tenseur de diffusion</term><term>Jeune adulte</term><term>Mâle</term><term>Phénomènes génétiques</term><term>Études de cohortes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">The degree to which genetic factors influence brain connectivity is beginning to be understood. Large-scale efforts are underway to map the profile of genetic effects in various brain regions. The NIH-funded Human Connectome Project (HCP) is providing data valuable for analyzing the degree of genetic influence underlying brain connectivity revealed by state-of-the-art neuroimaging methods. We calculated the heritability of the fractional anisotropy (FA) measure derived from diffusion tensor imaging (DTI) reconstruction in 481 HCP subjects (194/287 M/F) consisting of 57/60 pairs of mono- and dizygotic twins, and 246 siblings. FA measurements were derived using (Enhancing NeuroImaging Genetics through Meta-Analysis) ENIGMA DTI protocols and heritability estimates were calculated using the SOLAR-Eclipse imaging genetic analysis package. We compared heritability estimates derived from HCP data to those publicly available through the ENIGMA-DTI consortium, which were pooled together from five-family based studies across the US, Europe, and Australia. FA measurements from the HCP cohort for eleven major white matter tracts were highly heritable (h<sup>2</sup>=0.53–0.90, p<10<sup>−5</sup>), and were significantly correlated with the joint-analytical estimates from the ENIGMA cohort on the tract and voxel-wise levels. The similarity in regional heritability suggests that the additive genetic contribution to white matter microstructure is consistent across populations and imaging acquisition parameters. It also suggests the overarching genetic influence provides an opportunity to define a common genetic search space for future gene-discovery studies. Uniquely, the measurements of additive genetic contribution performed in this study can be repeated using online genetic analysis tools provided by the HCP ConnectomeDB web application.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Almasy, Laura" sort="Almasy, Laura" uniqKey="Almasy L" first="Laura" last="Almasy">Laura Almasy</name><name sortKey="Andersson, Jesper" sort="Andersson, Jesper" uniqKey="Andersson J" first="Jesper" last="Andersson">Jesper Andersson</name><name sortKey="Auerbach, Eddie" sort="Auerbach, Eddie" uniqKey="Auerbach E" first="Eddie" last="Auerbach">Eddie Auerbach</name><name sortKey="Bastin, Mark E" sort="Bastin, Mark E" uniqKey="Bastin M" first="Mark E." last="Bastin">Mark E. Bastin</name><name sortKey="Behrens, Timothy" sort="Behrens, Timothy" uniqKey="Behrens T" first="Timothy" last="Behrens">Timothy Behrens</name><name sortKey="Blangero, John" sort="Blangero, John" uniqKey="Blangero J" first="John" last="Blangero">John Blangero</name><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name><name sortKey="Brouwer, Rachel M" sort="Brouwer, Rachel M" uniqKey="Brouwer R" first="Rachel M." last="Brouwer">Rachel M. Brouwer</name><name sortKey="Curran, Joanne" sort="Curran, Joanne" uniqKey="Curran J" first="Joanne" last="Curran">Joanne Curran</name><name sortKey="De Geus, Eco Jc" sort="De Geus, Eco Jc" uniqKey="De Geus E" first="Eco Jc" last="De Geus">Eco Jc De Geus</name><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name><name sortKey="Den Braber, Anouk" sort="Den Braber, Anouk" uniqKey="Den Braber A" first="Anouk" last="Den Braber">Anouk Den Braber</name><name sortKey="Dezubicaray, Greig I" sort="Dezubicaray, Greig I" uniqKey="Dezubicaray G" first="Greig I" last="Dezubicaray">Greig I. Dezubicaray</name><name sortKey="Duggirala, Ravi" sort="Duggirala, Ravi" uniqKey="Duggirala R" first="Ravi" last="Duggirala">Ravi Duggirala</name><name sortKey="Fox, Peter" sort="Fox, Peter" uniqKey="Fox P" first="Peter" last="Fox">Peter Fox</name><name sortKey="Glahn, David C" sort="Glahn, David C" uniqKey="Glahn D" first="David C." last="Glahn">David C. Glahn</name><name sortKey="Hariri, Ahmad" sort="Hariri, Ahmad" uniqKey="Hariri A" first="Ahmad" last="Hariri">Ahmad Hariri</name><name sortKey="Hong, L Elliot" sort="Hong, L Elliot" uniqKey="Hong L" first="L Elliot" last="Hong">L Elliot Hong</name><name sortKey="Hulshoff Pol, Hilleke E" sort="Hulshoff Pol, Hilleke E" uniqKey="Hulshoff Pol H" first="Hilleke E." last="Hulshoff Pol">Hilleke E. Hulshoff Pol</name><name sortKey="Jahanshad, Neda" sort="Jahanshad, Neda" uniqKey="Jahanshad N" first="Neda" last="Jahanshad">Neda Jahanshad</name><name sortKey="Jbabdi, Saad" sort="Jbabdi, Saad" uniqKey="Jbabdi S" first="Saad" last="Jbabdi">Saad Jbabdi</name><name sortKey="Kahn, Rene" sort="Kahn, Rene" uniqKey="Kahn R" first="Rene" last="Kahn">Rene Kahn</name><name sortKey="Kochunov, Peter" sort="Kochunov, Peter" uniqKey="Kochunov P" first="Peter" last="Kochunov">Peter Kochunov</name><name sortKey="Landman, Bennett" sort="Landman, Bennett" uniqKey="Landman B" first="Bennett" last="Landman">Bennett Landman</name><name sortKey="Lemaitre, Herve" sort="Lemaitre, Herve" uniqKey="Lemaitre H" first="Hervé" last="Lemaitre">Hervé Lemaitre</name><name sortKey="Lenglet, Christophe" sort="Lenglet, Christophe" uniqKey="Lenglet C" first="Christophe" last="Lenglet">Christophe Lenglet</name><name sortKey="Marcus, Daniel" sort="Marcus, Daniel" uniqKey="Marcus D" first="Daniel" last="Marcus">Daniel Marcus</name><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><name sortKey="Mcintosh, Andrew" sort="Mcintosh, Andrew" uniqKey="Mcintosh A" first="Andrew" last="Mcintosh">Andrew Mcintosh</name><name sortKey="Mcmahon, Katie L" sort="Mcmahon, Katie L" uniqKey="Mcmahon K" first="Katie L." last="Mcmahon">Katie L. Mcmahon</name><name sortKey="Mitchell, Braxton" sort="Mitchell, Braxton" uniqKey="Mitchell B" first="Braxton" last="Mitchell">Braxton Mitchell</name><name sortKey="Moeller, Steen" sort="Moeller, Steen" uniqKey="Moeller S" first="Steen" last="Moeller">Steen Moeller</name><name sortKey="Nichols, Thomas E" sort="Nichols, Thomas E" uniqKey="Nichols T" first="Thomas E." last="Nichols">Thomas E. Nichols</name><name sortKey="Olvera, Rene L" sort="Olvera, Rene L" uniqKey="Olvera R" first="Rene L" last="Olvera">Rene L. Olvera</name><name sortKey="Patel, Binish" sort="Patel, Binish" uniqKey="Patel B" first="Binish" last="Patel">Binish Patel</name><name sortKey="Peterson, Charles" sort="Peterson, Charles" uniqKey="Peterson C" first="Charles" last="Peterson">Charles Peterson</name><name sortKey="Ritchie, Stuart" sort="Ritchie, Stuart" uniqKey="Ritchie S" first="Stuart" last="Ritchie">Stuart Ritchie</name><name sortKey="Sotiropoulos, Stamatios N" sort="Sotiropoulos, Stamatios N" uniqKey="Sotiropoulos S" first="Stamatios N" last="Sotiropoulos">Stamatios N. Sotiropoulos</name><name sortKey="Sprooten, Emma" sort="Sprooten, Emma" uniqKey="Sprooten E" first="Emma" last="Sprooten">Emma Sprooten</name><name sortKey="Starr, John" sort="Starr, John" uniqKey="Starr J" first="John" last="Starr">John Starr</name><name sortKey="Sussmann, Jessika" sort="Sussmann, Jessika" uniqKey="Sussmann J" first="Jessika" last="Sussmann">Jessika Sussmann</name><name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M." last="Thompson">Paul M. Thompson</name><name sortKey="Ugurbil, Kamil" sort="Ugurbil, Kamil" uniqKey="Ugurbil K" first="Kamil" last="Ugurbil">Kamil Ugurbil</name><name sortKey="Van Essen, David C" sort="Van Essen, David C" uniqKey="Van Essen D" first="David C." last="Van Essen">David C. Van Essen</name><name sortKey="Van T Ent, Dennis" sort="Van T Ent, Dennis" uniqKey="Van T Ent D" first="Dennis" last="Van T Ent">Dennis Van T Ent</name><name sortKey="Vanhulzen, Kimm" sort="Vanhulzen, Kimm" uniqKey="Vanhulzen K" first="Kimm" last="Vanhulzen">Kimm Vanhulzen</name><name sortKey="Wardlaw, Joanna" sort="Wardlaw, Joanna" uniqKey="Wardlaw J" first="Joanna" last="Wardlaw">Joanna Wardlaw</name><name sortKey="Williamson, Douglas E" sort="Williamson, Douglas E" uniqKey="Williamson D" first="Douglas E" last="Williamson">Douglas E. Williamson</name><name sortKey="Winkler, Anderson" sort="Winkler, Anderson" uniqKey="Winkler A" first="Anderson" last="Winkler">Anderson Winkler</name><name sortKey="Wright, Margie" sort="Wright, Margie" uniqKey="Wright M" first="Margie" last="Wright">Margie Wright</name><name sortKey="Wright, Susan N" sort="Wright, Susan N" uniqKey="Wright S" first="Susan N" last="Wright">Susan N. Wright</name><name sortKey="Yacoub, Essa" sort="Yacoub, Essa" uniqKey="Yacoub E" first="Essa" last="Yacoub">Essa Yacoub</name><name sortKey="Zwiers, Marcel P" sort="Zwiers, Marcel P" uniqKey="Zwiers M" first="Marcel P." last="Zwiers">Marcel P. Zwiers</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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